What is Onglyza (Saxagliptin) 2.5mg?
Onglyza 2.5mg is an oral antidiabetic agent that contains 2.5mg of saxagliptin. Saxagliptin is a competitive inhibitor of the enzyme dipeptidyl peptidase-4 (DPP-4). Following ingestion, incretin hormones like glucose-dependent insulinotropic polypeptide (GIP) and glucagon-like peptide-1 (GLP-1) are secreted from the small intestine into the bloodstream. These hormones are responsible for stimulating the beta cells in the pancreas in order to release insulin in a glucose-dependent manner. Besides that, GLP-1 also helps to lessen the release of glucagon (peptide hormone that converts stored glycogen into glucose) from the pancreatic alpha cells, reducing hepatic glucose output. However, these incretin hormones are inactivated by the DPP-4 enzymes within minutes. As a result, patients with type 2 diabetes mellitus will experience hyperglycemia if their condition is not controlled.
What is it used for?
Administration of Onglyza 2.5mg (saxagliptin) helps to reduce elevated blood glucose levels by slowing down the inactivation of incretin hormones, resulting in increased concentration of the hormones in the bloodstream. This results in reduced fasting and postprandial glucose concentrations in patients with type 2 diabetes mellitus. There are two strengths of Onglyza available—2.5mg or 5mg—and patients will be prescribed either strength depending on the severity of their medical condition. The medication should be taken once a day, with or without food.
Why use this drug?
This medication is prescribed as an effective adjunct therapy alongside diet control and exercise to improve glycemic control in patients with type 2 diabetes mellitus.Click to read more Click to read less
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