- Absolute Insulin Deficiency [Read It]
- Diabetes and Genetics [Read It]
- Peanut Butter and Diabetes [Read It]
- The Role of Statins in Diabetes Treatment [Read It]
Buy Adlyxin Pens Online From Canada
What is Adlyxin?
Adlyxin (lixisenatide) belongs to a class of drugs called glucagon-like peptide-1 (GLP-1) receptor agonists. This injectable medication may help patients with type 2 diabetes control blood sugar levels.
What is it used for?
Adlyxin is prescribed to adult patients with type 2 diabetes mellitus. It is used as an adjunctive treatment to exercise and diet for the improvement of blood glucose control. The drug is not indicated for the treatment of type I diabetes or diabetic ketoacidosis. Adlyxin should not be used in patients who have chronic pancreatitis (or previously had unexplained pancreatitis). Similarly, Adlyxin should not be used in the presence of gastroparesis. Keep in mind that Adlyxin is not a substitute for insulin injections.
How to take this medication
Prior to use, patients (and caregivers, if any) should be trained to prepare and use the pen correctly. A practice injection should be performed as part of the training. As with other injections, it is important to inspect the solution before use. Make sure the solution is colorless, clear and particulate free.
Inject Adlyxin subcutaneously into the upper arm, thigh or abdomen, using a different injection site each time. Patients are advised to rotate between injections sites (they should not inject into the same site for each dose). Adlyxin should be used one hour prior to the first meal of the day. In the case of a missed dose, patients should use the injectable one hour before the next meal. To ensure the safe use of Adlyxin, patients should not share their pens under any circumstances.
How does this drug work?
Adlyxin contains lixisenatide as its medicinal ingredient. Through the agonism of GLP-1 receptors, Lixisenatide is able to decrease glucagon secretion and increase glucose-dependent insulin. It is believed that lixisenatide promotes glucose-stimulated insulin exocytosis by beta islet cells, resulting in an increased glucose uptake. Ultimately, this leads to a drop in blood sugar levels. Plus, lixisenatide is known to slow gastric emptying. By activating the GLP-1 receptors in the gastrointestinal (GI) tract, Adlyxin delays gastric emptying, thereby controlling postprandial blood sugar levels.
Chemically, lixisenatide is able to activate adenylyl cyclase, subsequently increasing the concentration of cellular cyclic adenosine monophosphate. This leads to the activation of several chemical substances (e.g. protein kinase A or PKA, Epac1 and Epac2), all of which are involved in the “amplification” pathway. The activation of this amplification pathway will contribute to the increase of glucose-stimulated insulin secretion.
Initially, it is recommended to use Adlyxin once a day for two weeks. Then, from day-15 onwards, use a maintenance dose of 20mcg once per day.
- Nausea and vomiting
- Feeling dizzy
In order to prevent allergy reaction, Adlyxin should not be used in patients with known hypersensitivity to lixisenatide or any other inactive ingredients. Patients who had angioedema or anaphylaxis from the use of another GLP-1 receptor agonist should be monitored closely while they are on Adlyxin. They may be more susceptible to developing anaphylaxis.
This is not an exhaustive list of all the possible side effects of Adlyxin. Some patients may experience side effects other than the ones listed in this section.