What is Tradjenta (Linagliptin) 5mg?
Tradjenta 5mg is an oral antihyperglycemic agent that contains 5mg of linagliptin, a type of dipeptidyl peptidase-4 (DPP-4) enzyme. This DPP-4 enzyme is responsible for initiating the breakdown of incretin hormones, such as glucagon-like peptide-1 (GLP-1), and glucose-dependent insulinotropic polypeptide (GIP). These incretin hormones are usually released at a low basal level throughout the day and in higher quantities in response to food intake and digestion. The incretin hormones stimulate the pancreatic beta cells to release insulin in a glucose-dependent manner. GLP-1 has an additional function in the regulation of glucose homeostasis, whereby it helps to reduce the release of glucagon from the pancreatic alpha cells. However, these incretin hormones are deactivated within minutes by DPP-4 enzyme, resulting in a tremendous spike in blood glucose level of diabetic patients, especially after meals. Tradjenta 5mg, being a potent DPP-4 enzyme inhibitor, stops the activity of the DPP-4 enzyme, causing an increased level of incretin hormones, and reduced fasting and postprandial blood glucose levels.
What is it used for?
Tradjenta 5mg is prescribed alongside diet control and an exercise regime for type 2 diabetic patients to better regulate their glycemic control. However, this drug must not be prescribed for patients with type 1 diabetes or diabetic ketoacidosis. The initial daily dosage of Tradjenta 5mg for adults is one tablet, taken once daily, with or without food. If this medicine is administered in combination with an insulin secretagogue or insulin, then a lower dose of insulin secretagogue or insulin should be prescribed to prevent episodes of hypoglycemia.
Why use this medication?
This medication can be used as a combination therapy with other antidiabetic medications and insulins or as a monotherapy to help manage symptoms of diabetes.
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