What is Komboglyze 2.5mg/1000mg?
Komboglyze is a combination oral antidiabetic drug (OAD) that is composed of two main ingredients: 2.5mg of saxagliptin and 1000mg of metformin. Saxagliptin is an orally active antihyperglycemic agent that functions by inhibiting the action of the dipeptidyl peptidase-4 (DPP-4) enzyme. Incretin hormones like glucagon-like peptide-1 (GLP-1) and glucose-dependent insulinotropic polypeptide (GIP) are released following an oral glucose load. These incretin hormones promote the release of insulin in a glucose-dependent manner from pancreatic beta cells. GLP-1 also slows down the release of glucagon, which is a peptide hormone that converts glycogen into glucose, from the pancreatic alpha cells. This results in the reduced production of glucose in the liver. However, these incretin hormones are almost instantly inactivated by DPP-4, which will lead to an increased level of blood glucose.
What is it used for?
Since Komboglyze is a potent DPP-4 inhibitor, it will inhibit the action of the DPP-4 enzyme, resulting in an increased level of incretin hormones, and consequently reduced fasting and postprandial blood glucose readings. Another component in Komboglyze—metformin—is a potent biguanide, which also regulates blood glucose level by increasing insulin sensitivity for better cellular uptake and usage of glucose. Metformin also slows down the production and absorption of glucose in the liver and intestine. The starting daily dose of Komboglyze for patients who had not taken saxagliptin is based on the current dose of metformin, with additional 2.5mg of saxagliptin taken twice daily. The maximum daily dose is 5mg of saxagliptin and 2000mg of metformin. This drug should be taken twice daily with food to reduce any gastrointestinal side effects associated with metformin.
Why use this drug?
Use medication as part of an overall diabetes management plan that includes a healthy diet and regular exercise to successfully treat type 2 diabetes mellitus. Diabetic patients who are already on separate saxagliptin and metformin tablets may be also switched to Komboglyze instead. Komboglyze can also be used concomitantly with other OADs, or even insulin, for better glycemic control.Click to read more Click to read less
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