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Trulicity VS Bydureon

Trulicity VS Bydureon

Trulicity vs Bydureon

Trulicity (dulaglutide) and Bydureon (exenatide) are prescription medications of the drug class incretin mimetics prescribed for diabetes. They are both GLP-1 (glucagon-like peptide-1) receptor agonists, which are a class of non-insulin medications.

What are these drugs used for?

Both medications are used to treat type 2 diabetes by improving blood sugar control. As such, they can also help patients achieve weight loss.

How to take them

Dulaglutide and exenatide are taken differently. Trulicity is administered via subcutaneous injection in the thigh, stomach, or upper arm area once weekly. It comes in a ready-to-use pen with an automatic injector.

Bydureon is available as a powder that requires mixing or as a pre-filled pen. It is administered once weekly and is injected under the skin.

Trulicity and Bydureon side effects

Trulicity and Bydureon are both safe medications that were approved in 2014 and 2012, respectively. However, they may cause some side effects.

Trulicity side effects

Common side effects

  • Diarrhea
  • Nausea
  • Vomiting

Severe side effects

  • Allergic reaction
  • Severe diarrhea
  • Problems breathing

Bydureon side effects

Common side effects

  • Diarrhea
  • Nausea
  • Vomiting

Severe side effects

  • Fever
  • Loss of consciousness
  • Seizures


When considering dulaglutide vs exenatide, the dosage varies slightly. Trulicity is typically administered at a weekly dose of 0.75 mg. It may be adjusted up to 1.5 mg once a week. Bydureon is administered at a dose of 2 mg once per week.


Disclaimer: Please note that the contents of this community article are strictly for informational purposes and should not be considered as medical advice. This article, and other community articles, are not written or reviewed for medical validity by Canadian Insulin or its staff. All views and opinions expressed by the contributing authors are not endorsed by Canadian Insulin. Always consult a medical professional for medical advice, diagnosis, and treatment.
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