THANKS FOR VISITING - CLICK TO GET STARTED
Contact us
Customer Service Hours
Mon-Fri 9AM to 6:00PM EST
Email service@canadianinsulin.com
Phone 1-844-560-7790
Fax 1-866-951-0118

Pioglitazone (Actos) Mechanism of Action

Pioglitazone (Actos) Mechanism of Action

What is Pioglitazone (Actos)?

Pioglitazone is an oral anti-diabetic agent that is useful in regulating blood sugar levels in patients suffering from type 2 diabetes mellitus. It acts primarily by increasing the sensitivity of fat, muscle, and liver cells to the hormone insulin. This results in significantly lower levels of blood sugar, insulin, and sugar-coated red blood cells (i.e. HBA1C which indicates control of diabetes within the last three months). Moreover, it can also reduce the sugar output by the liver, improve the levels of good cholesterol, and may even preserve the pancreas cells that secrete insulin where normally they would degrade as the disease progresses.

Pioglitazone Mechanism of Action

When pioglitazone is in the body, it works by binding to receptors on the cell surface called peroxisome proliferator activated receptor (PPAR-gamma). This receptor is found throughout the fat, muscle, and liver cells and activates the expression of a protein called glucose transporter GLUT4 which increases the sugar uptake. Insulin is further sensitized by chemical components called tumor necrosis factor alfa, resistin, and adiponectin. The free fatty acid storage shifting from non-fat cells to fat cells also enhances insulin action. A redistribution of fat stores also occurs, where fat cells deep in the organs are transferred to dermal layers that are more insulin sensitive. In a 24-week study, patients given pioglitazone were found to have a 14.9% increase in the levels of high-density lipoprotein (good cholesterol). The overall metabolic effects are contributed by these known mechanisms. Pioglitazone usually takes two hours from the time it enters the digestive tract to be present in the body system, and it takes about seven days for it to achieve a steady level of concentration. 

If you are taking this medication and still have questions about how it works, contact your doctor for more information.


---

Disclaimer: Please note that the contents of this community article are strictly for informational purposes and should not be considered as medical advice. This article, and other community articles, are not written or reviewed for medical validity by Canadian Insulin or its staff. All views and opinions expressed by the contributing authors are not endorsed by Canadian Insulin. Always consult a medical professional for medical advice, diagnosis, and treatment.
Reset Your Password

Please enter your Username below and we will send a new password to the email associated with your account. Check your spam folder if you do not receive your new password.

Still having trouble logging in?

If you’re unable to log in, please call our customer service at 1-844-560-7790.