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What is Nesina (Alogliptin) Used For? Side Effects and Dosage

What is Nesina (Alogliptin) Used For? Side Effects and Dosage

What is Nesina (Alogliptin)?

Alogliptin is a medication that is indicated for people with type 2 diabetes who are not achieving sufficient levels of glycemic control for optimal health. An oral anti-diabetic drug, it can be used as an adjunct to a good diet and plenty of exercise for type 2 diabetics who cannot use metformin due to contraindications or intolerance.

When diet and exercise alone do not provide adequate glycemic control, alogliptin can be used in combination with metformin, sulfonylureas, pioglitazone, and/or insulin.

The alogliptin brand name is Nesina. The Nesina drug class is dipeptidyl peptidase-4 (gliptin) inhibitor (gliptin). It was developed by Syrrx, which was acquired by Takeda Pharmaceutical Company in 2005. The drug was approved for use by the Food and Drug Administration (FDA) in January 2013.

What is it used for?

Nesina is used by type 2 diabetics to achieve stable blood glucose levels, especially when other antidiabetic agents, like metformin and/or sulfonylureas, do not elicit the desired level of glucose stability.

This medication is not established for safety or efficacy in geriatric patients (>65 years of age) or pediatric patients (<18 years), so use of Nesina or a Nesina generic is not recommended in these groups.

How to take Alogliptin

It is necessary to titrate and closely monitor the dosage of Nesina based on the patient’s renal function and performance. A full assessment of renal function is highly recommended before a patient embarks on therapy with Nesina. These tests should be repeated at regular intervals during treatment to establish an efficacy regime.

No dosage adjustment is generally necessary based on the age of the patient, however dosing should be conservatively administered in patients of advanced age because of the possibility of renal failure.

Nesina side effects

Nesina was generally well-tolerated in controlled clinical studies. Serious side effects were rare. As with any diabetes-controlling medication, Nesina can induce a potentially dangerous state called hypoglycemia. It is unlikely to cause weight gain and the risk of hypoglycemia is low.

Common side effects

  • Headache
  • Upper respiratory tract infection
  • Nasopharyngitis

Severe side effects

  • Hypoglycemia
  • Hypersensitivity reactions
  • Renal impairment

Dosage

Nesina can be administered with or without food and it is taken as a once-daily tablet. The recommended starting dosage of Alogliptin is 25mg daily.

For a patient with moderate renal impairment, the dose is 12.5mg once daily. For severe renal impairment and end-stage renal disease, the dose is 6.25mg once daily.


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Disclaimer: Please note that the contents of this community article are strictly for informational purposes and should not be considered as medical advice. This article, and other community articles, are not written or reviewed for medical validity by Canadian Insulin or its staff. All views and opinions expressed by the contributing authors are not endorsed by Canadian Insulin. Always consult a medical professional for medical advice, diagnosis, and treatment.
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