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What is Jentadueto Used For? Side Effects and Dosage

What is Jentadueto, Its Side Effects and Dosage?

The first line treatment for type II diabetes is:

  • Diet
  • Weight control
  • Physical activity

If the blood glucose levels remain elevated despite adopting the above lifestyle measures, the next option is type II diabetes medications; most of the drugs are in tablet form. The doctor may prescribe Metformin since it’s the first line medication used to treat diabetes. If the blood glucose is still high after being on Metformin tablet, the physician may put a patient on combination therapy like Jentadueto.

What is Jentadueto?

It is available in the form of a tablet and prescribed to a person with type II diabetes whose blood sugar isn’t effectively regulated by the maximum tolerated Metformin dose alone or if a person is taking Linagliptin and Metformin as separate tablets. This medication is a combination of:

  • Linagliptin – it’s an oral antidiabetic which belongs to a family of drugs known as DPP-4(dipeptidyl 4) inhibitor. It lowers the blood glucose levels by inhibiting the breakdown of two incretin hormones known as glucose-dependent insulinotropic peptide and glucagon –like peptide-1. During food consumption, the hormones are produced as a response. The hormones make the beta cells release insulin due to the rising levels of blood glucose. Glucagon production is also reduced. The break-down of the hormone is stopped; hence Linagliptin increases the effects of these hormones in regulating the blood glucose.
  • Metformin – it’s a biguanide. The liver is an important organ which stores glucose and releases it between meal and at night. But due to the effects of Metformin, it releases reduced amount of glucose. Also, the drug makes body’s cells sensitive to the action of insulin hormone. So, the cells make use of insulin more effectively. Naturally, without the effects of the drug, once the carbs are broken down into their simplest form, they are absorbed quickly along the upper as well as the lower parts of the small intestines. Villi (small finger like projections) absorb the carbs, and then they are transported to the bloodstream and transferred to the muscles as well as the liver; Metformin interferes with part of this process. It delays the absorption of sugar from the intestines and into your bloodstream; hence there is minimal food spike in blood glucose levels.

Jentadueto can be used alone or together with other drugs like sulfonylureas. The drug is available under many brand names. The medication comes in the following strengths:

  • 2.5 mg /500 mg
  • 2.5 mg/850 mg
  • 2.5mg/1000 mg

How to Take

Take the medication exactly as directed by the medical care provider. The recommended starting dose of Jentadueto is individualized; it depends on the doses of the medication you are taking. As earlier mentioned, before the doctor prescribes this medication, you must be taking Metformin alone or with Linagliptin, but as separate tablets. The dose prescribed is taken twice daily (in the morning and evening), but with meals to reduce Jentuadueto side effects.

If the doctor has prescribed a different dose from your friend who has type II diabetes and on the medication, take the dose as prescribed; don’t take the drug in larger or smaller quantity or for a longer time than directed. If unclear on the dosage prescribed, contact the health practitioner just to be sure.

Low blood sugar can happen to anyone with diabetes, look out for symptoms like a headache, hunger, sweating, confusion, irritability, dizziness.

Also, be vigilant for signs of hyperglycemia (high blood sugar), for example, increased thirst and urination, hunger, dry mouth, dry skin, weight loss and blurred vision

Monitor blood glucose levels carefully in times of stress, illness or surgery as these may affect blood sugar levels. Contact the physician in such circumstances, since Jentadueto dose needs to be changed.

Inform the medical care provider about all the drugs you are taking; If possible, always have a list of all the prescription medicine, supplements, vitamins, herbs and over the counter drugs as you visit the hospital. If it is important to continue taking some drugs which may interact with Jentadueto, the health professional may alter the dose or take the necessary precautions.

Quit alcohol consumption during Jentadueto treatment and don’t skip meals as these may trigger low blood sugar.

The existence of medical conditions may interfere with the use of the drug. Make sure you inform the physician if you have medical problems like:

  • Vitamin B12 deficiency
  • Acute or unstable congestive heart failure
  • Excessive use of alcohol
  • Dehydration
  • A recent history of heart attack
  • Sepsis (it’s a serious infection)
  • Weakened physical condition
  • Diabetic ketoacidosis
  • Low blood pressure
  • Infection of any type
  • High cholesterol in the blood
  • Gallstones
  • Kidney disease
  • A history of pancreas problem

Jentadueto Side Effects

A patient on Jentadueto is at risk of its side effects which may be serious or mild. The negative effects listed here may not be experienced by all the patients on the drug. Most of the unwanted effects are manageable and clear without medical help over time.

Some common negative effects are:

  • Bloating
  • Diarrhea
  • Gas
  • Headache
  • Heartburn
  • Metallic taste in the mouth
  • Mouth ulcers
  • Nausea
  • Runny nose
  • Sore throat
  • Stuffy nose

If the just listed negative effects become irritating, contact the health practitioner for some tips to manage them. Nevertheless, some undesired effects need medical help right away and include:

  • Symptoms of anemia or low red blood cells for example pale skin, dizziness, unusual tiredness and shortness of breath
  • Symptoms of infection like fever or chills,  shortness of breath, severe diarrhea, prolonged dizziness, headache, stiff neck, or weight loss
  • Symptoms of pancreatitis such as abdominal pain, back pain, nausea, fever, chills, rapid heartbeat and swollen stomach
  • Symptoms of low blood sugar

For the following severe side effects, stop taking Jentadueto and seek medical attention right away:

  • Symptoms of lactic acidosis for example nausea, vomiting, abdominal pain, increased breathing rate, unusual muscle pain, dizziness, unusual tiredness, irregular heartbeat
  • Symptoms of severe allergic reaction such as abdominal cramps, difficulty breathing, nausea and vomiting, swelling of the face and throat
  • Symptoms of serious skin reaction like blistering, peeling, a rash affecting a large area of the body, a rash which spreads quickly, or a rash accompanied with fever or discomfort

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Disclaimer: Please note that the contents of this community article are strictly for informational purposes and should not be considered as medical advice. This article, and other community articles, are not written or reviewed for medical validity by Canadian Insulin or its staff. All views and opinions expressed by the contributing authors are not endorsed by Canadian Insulin. Always consult a medical professional for medical advice, diagnosis, and treatment.
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