WELCOME TO OUR NEW WEBSITE! -- LEARN MORE

Welcome to our new site!

We have updated our website to make it easier for you to place and track orders, refill your prescriptions, and view your account information. If you are already a customer, you will now be able to access your account directly. We have also enhanced our security to ensure the protection of your information.

IF YOU ARE ALREADY A CUSTOMER:
You will soon receive an email with a Username and Password that you can use to log in to your account. Be sure to check your spam folder for this email. If you do not receive this email, or if you have trouble logging into your account, please contact us toll-free at 1-844-560-7790.

IF YOU ARE A NEW CUSTOMER:
You can easily register a free account by clicking here. If you have any trouble, please call us at 1-844-560-7790.

We apologize for any inconvenience or issues you may experience as we continue adjusting our new website. We hope you will enjoy our updates and continue saving on your brand insulin!

Learn how to order on our new site by clicking here.


Contact us
Customer Service Hours
Mon-Fri 9AM to 6:30PM EST
Email service@canadianinsulin.com
Phone 1-844-560-7790
Fax 1-866-951-0118

What is the Difference between Glimepiride vs Glyburide?

What  is the Difference between Glimepiride vs Glyburide?

Both glimepiride and glyburide are oral anti-diabetic drugs that belong to the sulfonylureas class of drugs. They act by increasing insulin release from the pancreas, reducing sugar production from the liver, and elevating the sugar uptake sensitivity of the cells throughout the body. They should be taken with breakfast or the first main meal. As with many other oral anti-diabetic drugs, it has been reported that the efficacy of both glimepiride and glyburide decreases over time in a process called secondary failure. As much as 22% of patients undergo secondary failure within the first year of starting these drugs, and this progresses to as much as 50% in the second year. Both glimepiride and glyburide are absorbed rapidly during the first hour, while peak action occurs during the 2nd to 3rd hour.

Differences between glimepiride vs glyburide

There are some subtle differences when comparing glimepiride and glyburide. Glyburide gained FDA approval in 1984, while glimepiride gained it in 1995. Glyburide and glimepiride have been approved for type 2 diabetes mellitus, but only glyburide has been used for diabetes occurring during pregnancy. The Word Health Organization has also advocated for glyburide, not glimepiride, to be used during breastfeeding in diabetic patients since it is only present in a minute amount in breast milk. However, the organization also cautioned that the infant should be monitored for signs and symptoms of a low blood sugar level.

Side effects of glimepiride vs glyburide

For both products, and drugs in the sulfonylureas class, hypoglycemia is one of the most common side effects. Its occurrence has been reported to be as high as 7% per year in patients taking sulfonylureas. Diabetics must be able to identify the early symptoms of hypoglycemia because late recognition can result in serious health conditions. Symptoms such as hunger, nausea, numbness over the mouth and fingers, tremors, muscle weakness, blurred vision, uncontrolled yawning, and headaches should prompt an individual to seek consumption of sweet drinks or candies immediately before proceeding to contact medical support.

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