PPE NOW AVAILABLE - CLICK HERE TO SHOP
Contact us
Customer Service Hours
Mon-Fri 9AM to 6:00PM EST
Email service@canadianinsulin.com
Phone 1-844-560-7790
Fax 1-866-951-0118

Sitagliptin Vs. Saxagliptin

What is the Difference Between Sitagliptin vs Saxagliptin?

What are Sitagliptin and Saxagliptin?

Sitagliptin and Saxagliptin are hypoglycemic medications used for treating type 2 diabetes. The first line of treatment for type 2 diabetes mellitus is composed of metformin (for overweight patients). Sulfonylureas used to be the most popular anti-diabetic treatment in the United States until the introduction of metformin. However, sulfonylureas are associated with hypoglycemia, weight gain, beta cell death, and possible cardiac problems. Beyond metformin, DPP-4 inhibitors are popularly becoming another option for many.

DPP-4 Inhibitor Family – Gliptins

Gliptin is a recently introduced class of anti-hyperglycemic drugs with promising advantages. It works by blocking the action of dipeptidyl peptidase-4 (DPP-4), an enzyme that degrades the hormone incretin.

Incretin hormones helps in controlling the production of insulin and release of glucose; specifically, it stimulates the production of more insulin when it is needed, and moderates the production of glucose from the liver when it is not needed.

Various studies have acknowledged the safety and efficacy of gliptins, without promoting weight gain and with lower risk of hypoglycemia.

Difference between Sitagliptin vs. Saxagliptin

 

Sitagliptin (Januvia)

Saxagliptin (Onglyza)

Mode of Action Inhibits the action of DPP-4 enzyme that destroys GIP and GLP—hormones that are essential in reducing blood sugar levels. Controls blood sugar levels by reducing the breakdown of incretin hormones by inhibiting the action of DPP4.
Contraindications Contraindicated in patients with pancreatitis, gallstones, high triglyceride levels, and kidney problems. Increases the risk of heart failure, pancreatitis, and pancreatic cancer.
Efficacy Showed similar glycemic controls, but Saxagliptin demonstrated superiority for FBG (fasting blood glucose) control. Generally, safe and effective with lower risk of hypoglycemia compared to other oral anti-hyperglycemic agents.
Drug Combination Often prescribed alongside metformin, rosiglitazone, or pioglitazone. Often prescribed alongside Metformin.
Side Effects Headaches, abdominal pain, upper respiratory infection, nausea, hypoglycemia, and diarrhea. Headaches, vomiting, gastroenteritis, respiratory infection, urinary tract infection, and hypoglycemia.

---

Disclaimer: Please note that the contents of this community article are strictly for informational purposes and should not be considered as medical advice. This article, and other community articles, are not written or reviewed for medical validity by Canadian Insulin or its staff. All views and opinions expressed by the contributing authors are not endorsed by Canadian Insulin. Always consult a medical professional for medical advice, diagnosis, and treatment.
Reset Your Password

Please enter your Username below and we will send a new password to the email associated with your account. Check your spam folder if you do not receive your new password.

Still having trouble logging in?

If you’re unable to log in, please call our customer service at 1-844-560-7790.